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Enabling technology platforms for tissue engineering and regenerative medicine research

CHAN PUI BARBARA

SBS, iTERM, BME, CUHK

The research focus of the Tissue Engineering Lab at CUHK centers around bioengineering of cell- and biomaterial-based complex living tissue substitutes for tissue engineering and regenerative medicine applications. During the prolonged journey of developing engineered tissues for regenerative medicine purposes, we have faced many technical challenges associated with the major components of engineered tissues including stem cells, biomaterials and cell niche signals. A handful of technology platforms were developed to enable and facilitate research in tissue engineering and regenerative medicine research, including but are not limited to (1) a multiphoton microfabrication and micropatterning (MMM) technology to define the cell niche interactions; (2) a multi-level mechano-regulation (MMR) platform to facilitate mechano-characterization and manipulation of cells and tissues; and (3) a biomimetic biomacromolecular microencapsulation (BBM) platform to facilitate physiologically relevant scaffolding. In this seminar, the rationales, the technological capability and the relevant applications will be discussed.Ìý

Solid oxide electrolysis cell (SOEC) is a promising technology for COâ‚‚ electrolysis and subsequent conversion to useful chemicals. This thesis combines the experimental development of new cathode materials with system-level simulation to enhance the performance of SOECs for CO2 electrolysis and assess their applicability for fuel production. There are two components to the work: (1) proposing nanoparticle decorated perovskites cathode material and (2) integration of DAC, SOEC and synfuel production and asses its performance with techno-economic and environmental analysis.

In the experimental section, the focus was on the cathode material of the SOEC since it is the limiting factor for COâ‚‚ electrolysis.