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The research in the Martin Lab focuses on elucidating molecular mechanisms that promote the clearance of disease-causing proteins in neurodegeneration, particularly Huntington disease (HD) and amyotrophic lateral sclerosis (ALS). We focus on the cellular pathway know as autophagy, which delivers toxic proteins and damaged organelles to the lysosome for degradation and recycling. In particular, we are interested in how autophagy proteins are directed to membranes within the cell.

Our approach is highly collaborative and multi-faceted involving the identification of human SNPs, population genetics, protein characterization, chemical biology and high-resolution microscopy. Various aspects of these studies are performed in yeast, cell culture and mouse models.

• Neuroscience
• Disease Detection and Modeling
• Drug Discovery, Design and Delivery
• Biochemistry and Biophysics
• Molecular Genetics
• Physiology, Cell and Developmental Biology
• Bioinformatics, Systematics and Evolution
• Nanomaterials

• 2011 Ph.D. Cell Biology, University of Alberta, Canada
• 2003 B.Sc. Combined Honours in Biochemistry and Microbiology & Immunology, Dalhousie University, Canada

• Bluma Tischler Postdoctoral Fellowship, Faculty of Medicine – UBC
• Postdoctoral Fellowship, Michael Smith Foundation for Health Research (MSFHR)
• Postdoctoral Fellowship, Canadian Institutes for Health Research (CIHR)

• BIOL 302 - Functional Histology
  • Taught in 2020, 2021, 2022, 2023, 2024, 2025
• BIOL 472 - Cell Biology of Human Disease
  • Taught in 2021, 2022, 2023, 2024

* Only courses taught in the past 5 years are displayed.

• View Dale Martin's latest publications on his Google Scholar profile: