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UID:694ce2a44ff39
DTSTART;TZID=America/Toronto:20240326T130000
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URL:/waterloo-centre-microbial-research/events/wcmr-mon
 thly-meetup-1
LOCATION:AL - Arts Lecture Hall 200 University Avenue West AL-113 À¶Ý®ÊÓƵ 
 ON N2L 3G1 Canada
SUMMARY:WCMR Monthly Meetup
CLASS:PUBLIC
DESCRIPTION:> METATRANSCRIPTOMICS IDENTIFIES PATHOGENS AND HOST RESPO
 NSES\n> ASSOCIATED WITH ACUTE SINUSITIS IN CHILDREN\n> \n> ABSTRAC
 T: Acute sinusitis (AS) is a frequent cause of antibiotic\n> pre
 scriptions in children. Distinguishing bacterial AS from common\n>
  viral upper respiratory infections is crucial to prevent unneces
 sary\n> antibiotic use. We performed RNA-seq of nasopharyngeal sam
 ples from\n> 221 children with AS to better understand the etiol
 ogy of AS and the\n> impact of bacterial and viral infections o
 n host immune responses.\n> Metatranscriptomics detected three AS-a
 ssociated bacterial pathogens\n> with 87%/81% sensitivity/specificity
  (sens/spec) compared to\n> culture\, and 12 respiratory viruses 
 with 86%/92% sens/spec compared\n> to qRT-PCR. Metatranscriptomics 
 also detected 22 additional\n> pathogens not tested for in the c
 linical panel\, and facilitated\n> assembly of 205 viral genomes 
 including new strains of\n> coronaviruses\, respiratory syncytial v
 irus\, and enterovirus D68.\n> Lastly\, metatranscriptomic analysis
  identified distinct host immune\n> responses in individuals with
  bacterial versus viral infections. Our\n> study demonstrates the
  power of metatranscriptomics for\n> comprehensive analysis of AS
  etiology\, and reveals host responses\n> that could enable new 
 diagnostic approaches.
DTSTAMP:20251225T070716Z
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