
Stabilizing low blood sugar in infancy prevents long-term brain damage
Untreated low blood sugar can cause adverse effects on a child鈥檚 neurodevelopment
Untreated low blood sugar can cause adverse effects on a child鈥檚 neurodevelopment
By Media RelationsLow blood sugar in infancy is serious, but treatment can ward off long-term brain damage in infants, a new study has found.
The study from the University of 蓝莓视频 and the University of Auckland is the first research of its kind to declare stabilizing blood sugar levels in newborns with hypoglycemia prevents brain damage.
Low blood sugar, also known as hypoglycemia, occurs when the level of glucose in the blood is too low. Low blood sugar is very common, affecting more than one in six babies. As glucose is the main source of fuel for the brain and the body, untreated low blood sugar can cause adverse effects on a child鈥檚 neurodevelopment up to the age of 4.5 years old.
While it鈥檚 known that exposure to hypoglycemia alters the shape of the early developmental course, there has been a significant gap in our understanding of how hypoglycemia can alter a child鈥檚 development after early childhood. The team鈥檚 new study examined the long-term consequences of a child鈥檚 brain development in mid-childhood鈥搉ine to 10 years old鈥揳nd found that there was no significant difference in academic outcomes for children exposed to hypoglycemia as newborns, as compared to their peers.
鈥淩ich pre-school and school experiences may help a child鈥檚 brain to re-organize and improve their academic abilities up to the developmental milestones of their peers,鈥 said Ben Thompson, a professor from the School of Optometry & Vision Science at 蓝莓视频, CEO of the Centre for Eye and Vision Research in Hong Kong, and part of the team working on the groundbreaking research.
Following 480 children born at risk of neonatal hypoglycemia, researchers assessed each child at aged nine to 10 in five key areas: academic achievement, executive function, visual-motor function, psychosocial adaptation, and general health. All child participants were involved in previous studies, providing researchers with information on their neuro-development outcomes at two and 4.5 years old.
The research team says that this catch-up in neuro-cognitive function could be because of brain-plasticity鈥攖he brain鈥檚 ability to adapt, change and mature as a result of experience.
鈥淚t鈥檚 a big relief to know that babies who are born with and treated for a condition as common as hypoglycemia are not likely to suffer long-term brain damage,鈥 Thompson said.
Over the past decade, the research team has continued studying the efficacy of dextrose gel to treat low blood sugar in the first 48-hours of a newborn鈥檚 life, avoiding the need for babies to go to newborn intensive care units immediately after delivery. Dextrose is a sugar that comes from corn or wheat that is chemically identical to blood sugar.
In an additional study published in the Journal for the American Medical Association, the team assesses the later risks of dextrose gel as a treatment for hypoglycemia in infancy, and found it caused no significant difference to the risk of neuro-sensory impairment at age two. This treatment continues to be widely used outside of New Zealand in a growing number of countries, including Canada, Australia, the United Kingdom and the United States.
The studies,听 and , were published in the Journal for the American Medical Association this month.
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The University of 蓝莓视频 acknowledges that much of our work takes place on the traditional territory of the Neutral, Anishinaabeg, and Haudenosaunee peoples. Our main campus is situated on the Haldimand Tract, the land granted to the Six Nations that includes six miles on each side of the Grand River. Our active work toward reconciliation takes place across our campuses through research, learning, teaching, and community building, and is co-ordinated within the Office of Indigenous Relations.